abstract：:Imiquimod belongs to the family of synthetic small nucleotid-like molecules of imidazoquinolinamines. It is an immune response modifier with potent antiviral and antitumor effects, which are mediated by Toll-like receptors (TLR7 and TLR8). Imiquimod targets predominantly TLR7 expressing plasmacytoid dendritic cells an...

journal_title：Orvosi hetilap

authors： Kemény L,Nagy N

更新日期：2010-05-09 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disorder involving different organs and organ systems with consequent characteristic clinical and serologic symptoms. Despite of the improvement in lupus survival, approximately 10-20% of patients do not respond to traditional immune suppressive therapies. Relapses a...

journal_title：Orvosi hetilap

authors： Bazsó A,Poór G,Gergely P,Kiss E

更新日期：2010-05-02 00:00:00

abstract：:Nijmegen Breakage syndrome is a rare, autosomal recessive disorder characterized by severe, combined immunodeficiency, recurrent sinopulmonary infections, chromosomal instability, radiosensitivity, predisposition to malignancy, a "bird-like" facial appearance, progressive microcephaly, short stature, and mental retard...

journal_title：Orvosi hetilap

authors： Erdos M,Tóth B,Juhász P,Mahdi M,Maródi L

更新日期：2010-04-18 00:00:00

abstract：UNLABELLED:Penile cancer is a rare anomaly. Primary tumor and lymphnodes metastasis managements are essential. Nowadays, there is a growing wish for less invasive but curative treatment. AIMS AND METHODS:Newest opportunities of the management of penile cancer are reviewed according to the recent literature by the auth...

journal_title：Orvosi hetilap

authors： Nyirády P,Riesz P

更新日期：2010-04-11 00:00:00

abstract：UNLABELLED:Adjuvant systemic therapy reduces the likelihood of both local and distant relapses by eradicating micrometastases. AIM:To survey the adjuvant treatment of early breast cancer. METHODS:Author presents an overview of the systemic therapy of early breast cancer based on relevant literature and own experience...

journal_title：Orvosi hetilap

authors： Boér K

更新日期：2010-02-28 00:00:00

abstract：:Clinical presentation at diagnosis and disease course of both Crohn's disease (CD) and ulcerative colitis (UC) are heterogeneous and variable over time. During follow up, intestinal strictures or perforation may eventually develop at most patients with CD, and significant number of patients will undergo surgery. Much ...

journal_title：Orvosi hetilap

authors： Kiss LS,Lakatos PL

更新日期：2010-02-21 00:00:00

abstract：UNLABELLED:Pyoderma gangrenosum is a misleading designation for an idiopathic ulcerating cutaneous disease. The activity of pyoderma gangrenosum may or may not follow the activity of the inflammatory bowel disease. Visilizumab (Nuvion, PDL Bio Pharma, USA), a humanized IgG2 monoclonal antibody that binds to the human C...

journal_title：Orvosi hetilap

authors： Lorincz M,Kleszky M,Szalóki T Jr,Szalóki T

更新日期：2010-01-24 00:00:00

abstract：:The authors report on their experiences related to the first adult live donor liver transplantation performed in Hungary. The transplantation was done between brother and sister on 19th of November, 2007. The right lobe of the 33-year-old healthy male's donor liver (segments 5-8) was removed and implanted into the 23-...

journal_title：Orvosi hetilap

authors： Máthé Z,Kóbori L,Görög D,Fehérvári I,Nemes B,Gerlei Z,Doros A,Németh A,Mándli T,Fazakas J,Járay J

更新日期：2010-01-03 00:00:00

abstract：:Homeostasis and integrity of bowel mucosa is assured by well controlled mechanical, biochemical and immunological mechanisms. First line of defense is presented by the antimicrobial peptides (AMP), which form a continuous layer on the bowel surface, produced by intestinal specific (Paneth) and non-specific epithelial ...

journal_title：Orvosi hetilap

authors： Lapis K

更新日期：2009-11-22 00:00:00

abstract：:Nasoethmoid-orbital (NEO) fractures are typically resulted by a drastic, forceful blow to the central aspect of the head and nose, associated injuries to adjacent structures occur and involve the midface, anterior cranial fossa and the eye. Dislocated bony parts of the nose may be impacted into the intraorbital region...

journal_title：Orvosi hetilap

authors： Nemes I,Pácz M,Rothy A,Erményi I,Kocsis C

更新日期：2009-10-25 00:00:00

abstract：:Hypertrophic cardiomyopathy is a relatively common hereditary disorder, which is associated with cardiac morphologic and functional alterations. Echocardiography is a non-invasive, simple and easy-to-learn method to evaluate patients with cardiomyopathy. The aim of this review paper is to demonstrate the possible diag...

journal_title：Orvosi hetilap

authors： Nemes A,Geleijnse ML,Soliman OI,Anwar AM,Vletter WB,McGhie JS,Csanády M,Forster T,Ten Cate FJ

更新日期：2009-10-18 00:00:00

abstract：:According to epidemiological studies, the prevalence of pituitary adenomas is 16.5% and the majority of them are "incidentalomas". The symptoms of pituitary disorders are often non-specific; disturbances of pituitary function, compression symptoms, hypophysis apoplexy or accidental findings may help the diagnosis. The...

journal_title：Orvosi hetilap

authors： Mezosi E,Nemes O

更新日期：2009-09-27 00:00:00

abstract：:Patients seeking help from gastroenterologist have frequent complaints of changes in the quality and quantity of stool as well in the frequency of bowel movements. Definition of diarrhea includes: more than three bowel movements daily, more than 200 grams of the stool daily, and its water content exceeding 75-85%. Dia...

journal_title：Orvosi hetilap

authors： Bajor J,Beró T

更新日期：2009-08-30 00:00:00

abstract：:The progression from panel doctor's system towards family medicine in Hungary is reviewed, including professional, educational, financial and legal background. The main barriers for further development are insufficient human resources, inadequate financial foundation, administrative overload and the present legal regu...

journal_title：Orvosi hetilap

authors： Rurik I

更新日期：2009-08-23 00:00:00

abstract：UNLABELLED:Using quantitative sacroiliac joint scintigraphy for identifying patients with active sacroiliitis the diagnosis is relied on the abnormally high values of sacroiliac (SI) index. However, the normal range of SI index and the threshold for detecting the disease are still under discussion in the literature. A...

journal_title：Orvosi hetilap

authors： Bajner A

更新日期：2009-08-16 00:00:00

abstract：:Vaccination is the main strategy to control severe dehydrating gastroenteritis caused by rotaviruses in early childhood. The availability of new generation rotavirus vaccines has led to an intensification of strain surveillance worldwide, in part, to gauge the impact of the possible vaccine-driven immune selection of ...

journal_title：Orvosi hetilap

authors： László B,Czellár E,Deák J,Juhász A,Kovács J,Kónya J,Mészáros J,Mészner Z,Mihály I,Molnár P,Nyúl Z,Pátri L,Puskás E,Schneider F,Siffel C,Tóth A,Tóth E,Szucs G,Bányai K

更新日期：2009-08-02 00:00:00

abstract：UNLABELLED:In daily practice mycotic infections of the CNS have become more and more frequent. The main causes are the wide-ranging use of corticosteroids, immunosuppressive, cytostatic drugs and antibiotics, the spreading of AIDS, the increasing number of surviving immature newborns. To illustrate the diagnostic diffi...

journal_title：Orvosi hetilap

authors： Tahin B,Cooke J,Grasselly M,Iványi JL,Szima B,Bobest M,Ligeti E,Brittig F,Garzuly F,Tóth C

更新日期：2009-07-19 00:00:00

abstract：UNLABELLED:Whipple's disease is a chronic, systemic, relapsing bacterial illness, which is always fatal without treatment, and means a diagnostic challenge for both clinicians and pathologists. It occurs in Caucasian, white, middle-aged men in 80 % of the cases. CASE REPORT:The authors present three cases, and review ...

journal_title：Orvosi hetilap

authors： Fischer T,Tiboly M,Tóth P,Szenes M,Völgyi Z,Bali O,Gasztonyi B

更新日期：2009-07-12 00:00:00

abstract：:An attempt is made to give a concise overview on the evidence based physiological effects of static magnetic fields, with special emphasis on the Hungarian experiences. This area of science has developed significantly in recent years, parallel with the proliferation of nuclear magnetic resonance in medical diagnostics...

journal_title：Orvosi hetilap

authors： László J

更新日期：2009-07-05 00:00:00

abstract：UNLABELLED:Liver transplantation is a routinely used therapeutic choice in the treatment of end stage liver disease. Portal vein stenosis is a rare vascular complication after liver transplantation. We report the interventional radiological management of three cases of portal vein stenosis. AIM:The surgical management...

journal_title：Orvosi hetilap

authors： Doros A,Nemes B,Fehérvári I,Görög D,Gerlei Z,Németh A,Hartmann E,Deák AP,Fazakas J,Tóth S,Kóbori L

更新日期：2009-06-28 00:00:00

abstract：CASE REPORT:A 47 year old female with severe deficiency of three limbs visited our Genetic Counselling Clinic and asked us to give her a certificate that her complex limb deficiency was caused by thalidomide (Contergan). According to her explanation, her mother used this drug during pregnancy which was given to her by ...

journal_title：Orvosi hetilap

authors： Gidai J,Bács E,Czeizel E

更新日期：2009-06-21 00:00:00

abstract：:Penile deformities and tissue deficiencies can disturb sexual intercourse or make it impossible. The aim of the study is to summarize the different diseases according to their clinical appearance and pathological processes and to review operative methods and personal experiences. Surgical treatment of hypo- and epispa...

journal_title：Orvosi hetilap

authors： Kelemen Z

更新日期：2009-05-31 00:00:00

abstract：UNLABELLED:From time to time there is a surprise at the end of surgery - even after subtotal resection - when a vocal cord is observed on indirect laryngoscopy to be non-functional. Surgeons are highly individualistic and develop their own special ways of locating and protecting the nerve. The present study has tried t...

journal_title：Orvosi hetilap

authors： Altorjay A,Mucs M,Hamvas B,Füredi G,Botos B,Jaskó R,Bencsik Z,Rüll M,Szilágyi A,Csáti G

更新日期：2009-05-17 00:00:00

abstract：:Evolution of immunopathological diseases is usually slow and progressive. Non-differentiated collagen disease (NDC) or the term "undifferentiated connective tissue disease" (UCTD) represents a stage of disease where clinical symptoms and serological abnormalities suggest autoimmune disease, but they are not sufficient...

journal_title：Orvosi hetilap

authors： Bodolay E,Szegedi G

更新日期：2009-05-10 00:00:00

abstract：:Due to the rapidly increasing number of end-stage renal disease patients and the high costs of their treatment, all the aspects of kidney disease that may significantly affect clinical outcome (quality of life mortality) deserve increasing attention. It has been established and accepted that in addition to clinical/so...

journal_title：Orvosi hetilap

authors： Szeifert L,Adorjáni G,Zalai D,Novák M

更新日期：2009-03-29 00:00:00

abstract：UNLABELLED:The health status and social circumstances of medical professionals have been studied worldwide. However, there are only a few published studies pertaining to these topics in the countries of the former Eastern block. The present paper aimed at charting the state of health, the medical career path and some s...

journal_title：Orvosi hetilap

authors： Rurik I,Kalabay L

更新日期：2009-03-22 00:00:00

abstract：UNLABELLED:Hepatitis E virus (HEV) is one of a common cause of acute, fecally transmitted hepatitis in developing countries. Identification of HEV in indigenous human infection and in domestic pig raises the possibility that HEV infection is also a zoonosis. AIM/METHODS:Molecular detection and epidemiology of HEV in h...

journal_title：Orvosi hetilap

authors： Reuter G,Fodor D,Forgách P,Kátai A,Szucs G

更新日期：2009-03-01 00:00:00

abstract：:In pancreatic diabetes the whole of the Langerhans islets are damaged, which means that both the beta-cells and the alpha-cells are damaged. Unpredictable oscillations of blood glucose level are common due to malabsorption and maldigestion and one may count with explicit proneness to hypoglycaemia. The defence against...

journal_title：Orvosi hetilap

authors： Iván G

更新日期：2009-02-08 00:00:00

abstract：:It is known that dietary protein restriction slows the progression of chronic renal disease. If daily protein intake is less than 0.5-0.6 g/kgbw, the diet has to be supplemented with essential aminoacids/ketoacids. In this study the authors evaluate the long-term effect of low-protein diet supplemented with ketoacids ...

journal_title：Orvosi hetilap

authors： Molnár M,Szekeresné Izsák M,Nagy J,Figler M

更新日期：2009-02-01 00:00:00

abstract：:The oxygen uptake of the living organism through the cardiorespiratory system is one of the most basic physiological procedures, and the capacity for the oxygen uptake is an important parameter of both the health and the performance of the living organism. During the past decade several experiments have been performed...

journal_title：Orvosi hetilap

authors： Malomsoki J

更新日期：2009-01-25 00:00:00

abstract：:The author calls the attention, with reference to the four cases observed lately, to the reappearence of the Volkmann's ischaemic contracture, which was described at the end of the 19th century, but has been almost forgotten with the developing of traumatology. It discusses the reasons of development, the results and ...

journal_title：Orvosi hetilap

authors： Mészáros I

更新日期：2009-01-04 00:00:00

abstract：:We have used minimal invasive therapy in the treatment of pancreatic diseases for a long time. CT and/or ultrasound guided techniques have been used for the treatment of pancreatic pseudocysts for more than 20 years. The development of technology has also made an opportunity for the extensive use of laparoscopic surge...

journal_title：Orvosi hetilap

authors： Winternitz T

更新日期：2008-11-30 00:00:00

abstract：UNLABELLED:Recently laparoscopic cholecystectomy has become the standard operation in case of cholelithiasis. The range of contraindications has decreased, a previous abdominal surgery, a severe cholecystitis or gravidity are not self-evident contraindications any more. The advantages and benefits of laparoscopic inter...

journal_title：Orvosi hetilap

authors： Déry L,Galambos Z,Kupcsulik P,Lukovich P

更新日期：2008-11-09 00:00:00

abstract：:The autonomic nervous system has a crucial role in the genesis, maintenance and abruption of atrial fibrillation. The substrate and trigger mechanism of atrial fibrillation can be influenced by the changing autonomic tone. The authors summarize the current knowledge on the relationship between autonomic nervous system...

journal_title：Orvosi hetilap

authors： Lorincz I,Szabó Z,Simkó J,Szánthó E,Barta K,Füzi M,Szigeti G

更新日期：2008-10-26 00:00:00

abstract：:The clinical diagnostics and therapeutic standards applied in the routine management of human acute pancreatitis are based on the results of animal experiments and human studies performed in the past several decades. During this time period, a number of experimental acute pancreatitis models have been developed, which...

journal_title：Orvosi hetilap

authors： Takács T,Szabolcs A,Biczó G,Hegyi P,Rakonczay Z

更新日期：2008-10-19 00:00:00

abstract：:In recent years, the question of hemoglobin (Hb) stability in patients with chronic renal failure has attracted the interest of medical experts. One of the most important reasons behind this interest is that maintaining the hemoglobin level within the new narrower target range is highly challenging in clinical practic...

journal_title：Orvosi hetilap

authors： Kiss Z,Kulcsár I,Kiss I

更新日期：2008-10-12 00:00:00

abstract：UNLABELLED:The need of outcome measures from the patients' aspect emerges reasonably in the field of rapidly developing pediatric cardiac surgery and pediatric cardiology. The professional standards and the possibilities of applicability of quality of life measures are often unknown for medical doctors. This is particu...

journal_title：Orvosi hetilap

authors： Berkes A,Mogyorósy G

更新日期：2008-09-14 00:00:00

abstract：:Chronic pancreatitis is a persistent inflammatory disorder of the pancreas, characterized by destruction of the pancreatic parenchyma, maldigestion, chronic pain and diabetes mellitus. Genetic factors determining susceptibility to chronic pancreatitis can be classified in two groups: 1. rare gene mutations affecting t...

journal_title：Orvosi hetilap

authors： Sahin-Tóth M,Hegyi P,Tóth M

更新日期：2008-09-07 00:00:00

abstract：UNLABELLED:The noninvasive evaluation of right ventricular function is difficult, especially in postoperative complex congenital heart disease due to the special right ventricular geometry. The right ventricular dysfunction is a key factor in morbidity and mortality and in the determination of the necessity of reoperat...

journal_title：Orvosi hetilap

authors： Kádár K

更新日期：2008-08-10 00:00:00

abstract：:Inclusion body myositis is an acquired inflammatory muscle disease belonging to the family of idiopathic inflammatory myopathy with vacuole formation. Approximately 15-28% of idiopathic inflammatory myopathy patients suffer from inclusion body myositis. Early diagnosis is very important due to the slowly progressive d...

journal_title：Orvosi hetilap

authors： Váncsa A,Dankó K

更新日期：2008-07-27 00:00:00